The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis
Chiara Fucci, Massimo Resnati, Elena Riva, Tommaso Perini, Elena Ruggieri, Ugo Orfanelli, Francesca Paradiso, Floriana Cremasco, Andrea Raimondi, Elena Pasqualetto, Mario Nuvolone, Luca Rampoldi, Simone Cenci, Enrico Milan
Abstract
aggregates. Altogether, our data disclose a p62/FAM46C/FNDC3 circuit coordinating sustainable secretory activity and survival, providing an explanation for the MM-specific oncosuppressive role of FAM46C and uncovering potential therapeutic opportunities against cancer.
Topics & Concepts
Endoplasmic reticulumCell biologySecretionChemistryEndoplasmic-reticulum-associated protein degradationSecretory proteinSuppressorUnfolded protein responseBiologyBiochemistryGeneUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and Disease