Enantio‐ and Diastereoselective Synthesis of Homopropargyl Amines by Copper‐Catalyzed Coupling of Imines, 1,3‐Enynes, and Diborons
Srimanta Manna, Quentin Dherbassy, Gregory J. P. Perry, David J. Procter
Abstract
An efficient, enantio- and diastereoselective, copper-catalyzed coupling of imines, 1,3-enynes, and diborons is reported. The process shows broad substrate scope and delivers complex, chiral homopropargyl amines; useful building blocks on the way to biologically-relevant compounds. In particular, functionalized homopropargyl amines bearing up to three contiguous stereocenters can be prepared in a single step.
Topics & Concepts
StereocenterChemistryCatalysisCombinatorial chemistryCopperSubstrate (aquarium)Coupling (piping)Scope (computer science)Enantioselective synthesisOrganic chemistryMaterials scienceComputer scienceProgramming languageGeologyMetallurgyOceanographyOrganoboron and organosilicon chemistrySynthetic Organic Chemistry MethodsCatalytic Cross-Coupling Reactions