A Region of UNC-89 (Obscurin) Lying between Two Protein Kinase Domains Is a Highly Elastic Spring Required for Proper Sarcomere Organization
Hiroshi Qadota, Jasmine C. Moody, Leila Lesanpezeshki, Taylor Moncrief, Deborah Kitzler, Purnima Devaki Bhat, Siva A. Vanapalli, Andrés F. Oberhauser, Guy M. Benian
Topics & Concepts
SarcomereGene isoformBiologyObscurinTitinCoiled coilCell biologyProtein kinase domainMotor proteinCRISPRCaenorhabditis elegansMyosinSequence alignmentSignal transducing adaptor proteinGeneticsPeptide sequenceMyocyteMicrotubulePhosphorylationGeneMutantGenetics, Aging, and Longevity in Model OrganismsCardiomyopathy and Myosin StudiesMuscle Physiology and Disorders