Identification of the Active Catalyst for Nickel‐Catalyzed Stereospecific Kumada Coupling Reactions of Ethers
David D. Dawson, Victoria F. Oswald, Andy S. Borovik, Elizabeth R. Jarvo
Abstract
Abstract A series of nickel complexes in varying oxidation states were evaluated as precatalysts for the stereospecific cross‐coupling of benzylic ethers. These results demonstrate rapid redox reactions of precatalysts, such that the oxidative state of the precatalyst does not dictate the oxidation state of the active catalyst in solution. These data provide the first experimental evidence for a Ni 0 –Ni II catalytic cycle for a stereospecific alkyl–alkyl cross‐coupling reaction, including spectroscopic analysis of the catalyst resting state.
Topics & Concepts
StereospecificityCatalysisNickelChemistryAlkylCatalytic cycleCoupling reactionRedoxCombinatorial chemistryOrganic chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis