Circular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1
Xiaohai Cui, Boxiang Zhang, Li Baocheng, Xinju Li
Abstract
. Our study demonstrated that silencing of circ_0002360 enhanced the Taxol sensitivity and suppressed the malignant behaviors of Taxol-resistant NSCLC cells by miR-585-3p/GPRIN1 axis, providing novel targets for improving the anti-tumor efficacy of Taxol in NSCLC.
Topics & Concepts
Gene silencingCancer researchGene knockdownCell growthmicroRNAFlow cytometryBiologyApoptosisCircular RNAMolecular biologyChemistryBiochemistryGeneCircular RNAs in diseasesMicroRNA in disease regulationRNA Research and Splicing