pH-Sensitive magnetite mesoporous silica nanocomposites for controlled drug delivery and hyperthermia
Hasan Keshavarz, Alireza Khavandi, S. Alamolhoda, Mohammad Reza Naimi‐Jamal
Abstract
= 43 °C (pH simulating endosomes/hyperthermia) were 15 and 70%, respectively, so, drug release was increased with hyperthermia. To determine the biocompatibility of the nanogels, an MTT assay of L929 cells was performed for 24, 48 and 72 h. The results show high biocompatibility of nanogels even at high concentrations (over 80% cell viability after 72 h for all concentrations).
Topics & Concepts
BiocompatibilityMesoporous silicaDrug deliveryMagnetic hyperthermiaGlutaraldehydeHyperthermiaChitosanNuclear chemistrySelf-healing hydrogelsChemical engineeringMaterials scienceViability assayMesoporous materialNanocompositeMTT assayChemistryNanoparticleNanotechnologyMagnetic nanoparticlesPolymer chemistryChromatographyOrganic chemistryCellEngineeringBiochemistryMedicineCatalysisInternal medicineNanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesIron oxide chemistry and applications