Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype
Chiara De Santi, Frances K. Nally, Remsha Afzal, Conor P. Duffy, Stephen Fitzsimons, Stephanie Annett, Tracy Robson, Jennifer K. Dowling, Sally‐Ann Cryan, Claire E. McCoy
Abstract
model of LPS-induced acute inflammation, intraperitoneal administration of Arg2 TSB led to an overall decrease in systemic levels of pro-inflammatory cytokines. Overall, this proof-of-concept strategy represent a promising approach to modulating macrophage phenotype.
Topics & Concepts
ArginaseInflammationMacrophage polarizationMacrophageProinflammatory cytokineImmunologyPhenotypeCell biologyBiologyCancer researchArginineIn vitroBiochemistryGeneAmino acidImmune cells in cancerAdenosine and Purinergic SignalingImmune Response and Inflammation