Transmigration of magnetite nanoparticles across the blood–brain barrier in a rodent model: influence of external and alternating magnetic fields
Ruby Gupta, Anjali Chauhan, Tashmeen Kaur, Bijoy K. Kuanr, Deepika Sharma
Abstract
results revealed that the exposure to AMF transiently opened the tight junctions at the BBB, which, after 3 h of treatment, were observed to recover back to their comparable control levels. A biodistribution analysis of nanoparticles confirmed targeted accumulation of MNPs in the brain following dual targeting. This dual targeting approach was observed to open the tight junctions, thus increasing the transport of MNPs into the brain with higher specificity as compared to using EMF targeting alone, suggesting that a dual magnetic targeting-induced transport of MNPs across the BBB is an effective measure for delivery of therapeutics.
Topics & Concepts
Blood–brain barrierIn vivoTight junctionMagnetic nanoparticlesIn vitroBiodistributionBiophysicsPermeability (electromagnetism)ChemistryDrug deliveryMaterials scienceCell biologyNanotechnologyNanoparticleCentral nervous systemBiologyNeuroscienceBiochemistryMembraneBiotechnologyBarrier Structure and Function StudiesAdvanced Neuroimaging Techniques and ApplicationsNanoparticle-Based Drug Delivery