Flexible diaminodihydrotriazine inhibitors of Plasmodium falciparum dihydrofolate reductase: Binding strengths, modes of binding and their antimalarial activities
Sumalee Kamchonwongpaisan, Netnapa Charoensetakul, Choladda Srisuwannaket, Supannee Taweechai, Roonglawan Rattanajak, Jarunee Vanichtanankul, Danoo Vitsupakorn, Uthai Arwon, Chawanee Thongpanchang, Bongkoch Tarnchompoo, Tirayut Vilaivan, Yongyuth Yuthavong
Topics & Concepts
Dihydrofolate reductasePlasmodium falciparumChemistryMutantEnzymeAntifolateStereochemistryBiochemistryEnzyme inhibitorBinding siteBiologyMalariaOrganic chemistryAntimetaboliteImmunologyGeneToxicityHIV/AIDS drug development and treatmentQuinazolinone synthesis and applicationsBiochemical and Molecular Research