Design, synthesis and biological evaluation of seco-DSP/DCK derivatives reversing P-glycoprotein-mediated paclitaxel resistance in A2780/T cells
Weijie Wang, Qi Wan, Mengru Li, Feng Qu, Hongrui Liu, Ying Chen
Topics & Concepts
ChemosensitizerP-glycoproteinChemistryPaclitaxelRhodamine 123Multiple drug resistancePharmacologyATP-binding cassette transporterVerapamilEffluxhERGTransporterPotassium channelBiochemistryChemotherapyBiologyBiophysicsAntibioticsGeneGeneticsOrganic chemistryCalciumDrug Transport and Resistance MechanismsCancer therapeutics and mechanismsRNA Interference and Gene Delivery