Comparison of the effects of vitamin D and nasal calcitonin spray with nasal calcitonin spray on postoperative abdominal pain: A randomised controlled trial
Masoud Saadat Fakhr, Fatemeh Zahra Karimi, Kiana Rezvanfar, Delyar Mardmomen, Poorya Gholami, Zahra Amini, Koosha Amiri, Mahnaz Narimani Zamanabadi
Abstract
Postoperative pain control is critical after abdominal surgery. primary researches suggest that vitamin D and nasal calcitonin spray may have an effect in reducing postoperative pain. This study aims to compare postoperative abdominal pain, in patients who received a combination of Nasocalcin spray and vitamin D to those who received Nasocalcin spray. In this double-blind randomized clinical trial, 34 patient candidates for abdominal surgery were selected. They were randomly divided into 2 groups (group A (N = 17) received vitamin D and Nasocalcin spray, and group B (N = 17) received Nasocalcin spray). The drugs have been administered to patients 1 h before surgery. Equivalent amounts of Nasocalcin and intramuscular distilled water were administered to the calcitonin group. after the surgery Patients’' pain levels were measured using a visual analog scale (VAS) after they had gained full consciousness and 6, 12, and 24 h after surgery. the amount of narcotics injected in the first 24 h after surgery was monitored and compared between the two groups. There was no significant relation between the groups in terms of age (p = 0.98), gender distribution (p = 0.1), surgery duration (p = 0.35), and pain scores after surgery (p = 0.67). In comparison to group B, at 6 h (p = 0.007), 12 h (p = 0.001), and 24 h (p = 0.003), group A reported significantly less pain. There was a significant reduction in total narcotic injected (p = 0.003) in group A. Preoperative administration of vitamin D with nasal calcitonin spray improved postoperative pain control compared to nasal calcitonin. This non-opioid drug combination represents a preemptive medication for enhanced recovery after abdominal surgery.