Advances in the study of RNA-binding proteins in diabetic complications
Xinyue Chen, Jiaqiang Wu, Zhangwang Li, Jiashu Han, Panpan Xia, Yunfeng Shen, Jianyong Ma, Xiao Liu, Jing Zhang, Peng Yu
Abstract
BACKGROUND: It has been reported that diabetes mellitus affects 435 million people globally as a primary health care problem. Despite many therapies available, many diabetes remains uncontrolled, giving rise to irreversible diabetic complications that pose significant risks to patients' wellbeing and survival. SCOPE OF REVIEW: In recent years, as much effort is put into elucidating the posttranscriptional gene regulation network of diabetes and diabetic complications; RNA binding proteins (RBPs) are found to be vital. RBPs regulate gene expression through various post-transcriptional mechanisms, including alternative splicing, RNA export, messenger RNA translation, RNA degradation, and RNA stabilization. MAJOR CONCLUSIONS: Here, we summarized recent studies on the roles and mechanisms of RBPs in mediating abnormal gene expression in diabetes and its complications. Moreover, we discussed the potential and theoretical basis of RBPs to treat diabetes and its complications.