Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis
Liuhua Pei, Yifei Le, Hang Chen, Jiafan Feng, Zhijun Liu, Ji Zhu, Cui Wang, Lin Chen, Xiaobing Dou, Dezhao Lu
Topics & Concepts
PKM2Macrophage polarizationLiver injuryInflammationGlycolysisPyruvate kinaseSepsisAnaerobic glycolysisImmune systemPharmacologyCancer researchBiologyImmunologyMacrophageIn vitroBiochemistryMetabolismImmune cells in cancerCancer, Hypoxia, and MetabolismSphingolipid Metabolism and Signaling