Rational design of ERα targeting hypoxia turn-on fluorescent probes with antiproliferative activity for breast cancer
Qiuyu Meng, Baohua Xie, Xiaoyu Ma, Zhiye Hu, Fuling Zhou, Hai‐Bing Zhou, Chune Dong
Abstract
Several ERα targeting hypoxia turn-on fluorescent probes have been developed. The probes <bold>3</bold> and <bold>5</bold> displayed favorable hypoxia turn-on response and good antiproliferative activity in MCF-7 cells, and showed low cytotoxicity to normal cells.
Topics & Concepts
Hypoxia (environmental)FluorescenceTurn (biochemistry)CytotoxicityCancer researchChemistryBreast cancerCancer cellBiophysicsCell biologyCancerBiologyBiochemistryIn vitroMedicineInternal medicineOxygenOrganic chemistryPhysicsQuantum mechanicsCancer, Hypoxia, and MetabolismNanoplatforms for cancer theranosticsATP Synthase and ATPases Research