Simvastatin combined with bone marrow mesenchymal stromal cells (BMSCs) improve burn wound healing by ameliorating angiogenesis through SDF-1α/CXCR4 pathway.
Javad Mohajer Ansari, Parisa Ramhormozi, Ronak Shabani, Hamidreza Pazoki–Toroudi, Abazar Yari, Mahmood Barati, Mostafa Dahmardehei, Azar Babakhani, Maliheh Nobakht
Abstract
OBJECTIVES: Chemokines are wound mediators that promote angiogenesis during wound healing. We hypothesized that Simvastatin in combination with the bone marrow mesenchymal stromal cells (BMSCs) improve burn wound healing by ameliorating angiogenesis via SDF-1α/CXCR4 pathway. MATERIALS AND METHODS: wound closure, H&E and Trichorome staining, immunohistochemistry (IHC), real- time PCR, Western blot and tube formation assay. RESULTS: . CONCLUSION: Treatment of deep partial-thickness of burns with co-treatment of BMSCs and Simvastatin resulted in improved burn wound healing through up-regulating of SDF-1α/CXCR4 pathway.