NLRP3 Inflammasome and Inflammatory Diseases
Zheng Wang, Simei Zhang, Ying Xiao, Wunai Zhang, Shuai Wu, Tao Qin, Yangyang Yue, Weikun Qian, Li Li
Abstract
Almost all human diseases are strongly associated with inflammation, and a deep understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome composed of the NLRP3 protein, procaspase-1, and ASC plays a vital role in regulating inflammation. In this review, NLRP3 regulation and activation, its proinflammatory role in inflammatory diseases, interactions with autophagy, and targeted therapeutic approaches in inflammatory diseases will be summarized.
Topics & Concepts
InflammasomeProinflammatory cytokineInflammationAutophagyMechanism (biology)ImmunologyInflammatory responseMedicineBiologyApoptosisGeneticsEpistemologyPhilosophyInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideAutoimmune and Inflammatory Disorders Research