Deep learning-enhanced development of innovative antioxidant liposomal drug delivery systems from natural herbs
Xiaohe Zhang, Zhihang Zheng, Lina Xie, Minghao Yang, Jing Wang, Weiwei Wang, Shuyan Han, Zhen Zhang, Jun Wu
Abstract
bioavailability, but also mitigated oxidative stress injury after kidney acute ischemia/reperfusion. This was achieved by up-regulating antioxidant-related genes in target organs as well as ROS scavenging. Our findings highlight the potential of integrating deep learning-based compound screening with an engineered liposomal delivery platform in the research of oxidative stress and aging.
Topics & Concepts
LiposomeAntioxidantDrug deliveryReactive oxygen speciesOxidative damageMacromoleculeChemistryOxidative stressDrugNanotechnologyCombinatorial chemistryCell biologyBiochemistryPharmacologyMaterials scienceBiologyMedicinal Plants and Neuroprotection