Noncanonical Amino Acids: Bringing New-to-Nature Functionalities to Biocatalysis
Bart Brouwer, Franco Della‐Felice, Jan Hendrik Illies, Emilia Iglesias-Moncayo, Gérard Roelfes, Ivana Drienovská
Abstract
genetic incorporation of noncanonical amino acids exceeds the conventional 20 amino acids, opening new avenues for innovation. This review provides a comprehensive overview of applications of noncanonical amino acids in biocatalysis. We aim to examine the field from multiple perspectives, ranging from their impact on enzymatic reactions to the creation of novel active sites, and subsequent catalysis of new-to-nature reactions. Finally, we discuss the challenges, limitations, and promising opportunities within this dynamic research domain.
Topics & Concepts
ChemistryBiocatalysisAmino acidNanotechnologyCombinatorial chemistryBiochemical engineeringComputational biologyOrganic chemistryBiochemistryCatalysisReaction mechanismEngineeringBiologyMaterials scienceEnzyme Catalysis and ImmobilizationMicrobial Metabolic Engineering and BioproductionPhotosynthetic Processes and Mechanisms