Cytokine engineered NK-92 therapy to improve persistence and anti-tumor activity
Hyun Young Shin, Seil Jang, Hyeong Jung Woo, Jae-Hee Chung, Woon‐Hae Kim, Dong-Oh Kim, Min Ju Kang, Yu-Jin Lim, Omer Habib, Jungmin Lee, Sohae Yang, Dae Hee Lee, Minseok S. Kim
Abstract
. Furthermore, the experiment with a spheroid solid tumor model exhibited enhanced infiltration by MBP NK cells creating higher local effector-to-target ratio for efficient tumor killing. These results suggest MBP technology can be an effective utility for NK-92 cell engineering to increase anti-tumor activity and reduce potential adverse effects, providing a higher therapeutic index in clinical applications.
Topics & Concepts
CytokineImmunotherapyAutocrine signallingCancer researchTumor microenvironmentCancer immunotherapyImmune systemImmunologyChemistryCell biologyBiologyCell cultureGeneticsImmune Cell Function and InteractionCAR-T cell therapy researchRNA Interference and Gene Delivery