Litcius/Paper detail

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum

David S.M. Lee, Kathleen M. Cardone, David Zhang, Noah L. Tsao, Sarah Abramowitz, Pranav Sharma, John DePaolo, Mitchell Conery, Krishna G. Aragam, Kiran J. Biddinger, Ozan Dikilitas, Lily Hoffman‐Andrews, Renae Judy, Atlas Khan, Iftikhar J. Kullo, Megan J. Puckelwartz, Nosheen Reza, Benjamin A. Satterfield, Pankhuri Singhal, Penn Medicine Biobank, Giorgio Sirugo, Anurag Verma, Shefali S. Verma, Theodore Drivas, Zoltàn Arany, Thomas P. Cappola, Eric Carruth, Sharlene M. Day, Ron Do, Christopher M. Haggerty, Jacob Joseph, Elizabeth M. McNally, Girish N. Nadkarni, Anjali Owens, Daniel J. Rader, Marylyn D. Ritchie, Yan V. Sun, Benjamin F. Voight, Michael G. Levin, Scott M. Damrauer

2025Nature Genetics29 citationsDOIOpen Access PDF

Topics & Concepts

BiologyGenetic architectureAlleleAllele frequencyGeneticsGenetic variantsMinor allele frequencyHeart failureGenotypeGenePhenotypeInternal medicineMedicineCardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmiasRNA and protein synthesis mechanisms