Targeting clathrin-mediated endocytosis: recent advances in inhibitor development, mechanistic insights, and therapeutic prospects
Chao Zhang, Jialin Guo, Zixiao Liu, Xu-Hui Huang, Shiqi Dong, Chun Hu, Junhai Xiao
Abstract
), demonstrate improved precision. Future research must prioritize optimizing pharmacokinetics, reducing off-target effects, and exploiting emerging targets like endocytic accessory proteins (EAPs) to advance CME inhibitors toward clinical applications.
Topics & Concepts
Endocytic cyclePleckstrin homology domainEndocytosisComputational biologyDynaminGTPaseDrug discoveryBiologyAllosteric regulationSmall moleculeChemistrySignalling pathwaysBioinformaticsCell biologyNeuroscienceDruggabilitySignal transductionDrug developmentProtein–protein interactionUbiquitinCellular transport and secretionCell Adhesion Molecules ResearchMonoclonal and Polyclonal Antibodies Research