Design, synthesis, and biological evaluation of harmine derivatives as topoisomerase I inhibitors for cancer treatment
Yali Guo, Jingwen Yu, Yan Cao, Ke-Xin Cheng, Suo-Nan-Mu Dong-Zhi, Yanfei Zhang, Qingjia Ren, Yong Yin, Caolong Li
Topics & Concepts
HarmineChemistryApoptosisCell growthChalconeCell cultureCancer cellTopoisomeraseIC50ToxicityPharmacologyBiochemistryCancer researchCancerStereochemistryIn vitroBiologyGeneticsOrganic chemistrySynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsToxin Mechanisms and Immunotoxins