Divergent α-functionalization of cyclic amines <i>via</i> ring construction by molecular O<sub>2</sub> oxidized dearomatization and ring deconstruction by aromatization-driven C–C σ-bond cleavage
Fangzhi Hu, Liang Wang, Chunyan Ge, Xinyao Li, Zhanshuai Ding, Lubin Xu, Shuai‐Shuai Li
Abstract
An efficient approach to achieve the divergent α-C(sp<sup>3</sup>)–H functionalization of cyclic amines through an O<sub>2</sub> oxidized dearomatization/ring construction and aromatization-driven ring deconstruction/intermolecular functionalization strategy was developed.
Topics & Concepts
AromatizationRing (chemistry)Surface modificationChemistryCleavage (geology)Bond cleavageCyclic aminesMedicinal chemistryStereochemistryCombinatorial chemistryOrganic chemistryMaterials scienceCatalysisFracture (geology)Composite materialPhysical chemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions