Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA
Geon-Woo Kim, Aleem Siddiqui
Abstract
N6-methyladenosien (m6A) modifications recently have been implicated in the HBV life cycle. Previously, we observed that m6A modification occurs in the adenosine at nt 1907 of the HBV genome, and this modification regulates the viral life cycle.
Topics & Concepts
HBxBiologyUntranslated regionMessenger RNAMolecular biologyGene silencingViral proteinRNAHepatitis B virusThree prime untranslated regionTranslational frameshiftCoding regionTranscription (linguistics)Open reading frameMethyltransferaseAntiviral proteinVirologyMutantCell biologyFive prime untranslated regionViral replicationVirusGeneRegulation of gene expressionViral structural proteinSignal transductionGene expressionProtein biosynthesisRNA-binding proteinHepatitis B Virus StudiesBacteriophages and microbial interactionsRNA modifications and cancer