Identifying the Novel Gut Microbial Metabolite Contributing to Metabolic Syndrome in Children Based on Integrative Analyses of Microbiome-Metabolome Signatures
Jia Wei, Wen Dai, Xiongfeng Pan, Yan Zhong, Ningan Xu, Ping Ye, Jie Wang, Jina Li, Fei Yang, Jiayou Luo, Miyang Luo
Abstract
and illustrated the effects of the microbial metabolites on lipid synthesis and inflammation. The microbial metabolite all-trans-13, 14-dihydroretinol may be a new biomarker in the pathogenesis of MS, especially in obese children. These findings were not available in previous studies, and they provide new insights regarding the management of metabolic syndrome.
Topics & Concepts
MetabolomeMicrobiomeMetaboliteGut microbiomeBiologyMetabolomicsComputational biologyMetagenomicsIntestinal MicrobiomeGeneticsEvolutionary biologyBioinformaticsGeneBiochemistryDiet and metabolism studiesGut microbiota and healthDiet, Metabolism, and Disease