High Cost of Chimeric Antigen Receptor T-Cells: Challenges and Solutions
Edward R. Scheffer Cliff, Amar H. Kelkar, David A. Russler‐Germain, Frazer A. Tessema, Adam Raymakers, William B. Feldman, Aaron S. Kesselheim
Abstract
Chimeric antigen receptor (CAR) T-cells are a cellular immunotherapy with remarkable efficacy in treating multiple hematologic malignancies but they are associated with extremely high prices that are, for many countries, prohibitively expensive. As their use increases both for hematologic malignancies and other indications, and large numbers of new cellular therapies are developed, novel approaches will be needed both to reduce the cost of therapy, and to pay for them. We review the many factors that lead to the high cost of CAR T-cells and offer proposals for reform.
Topics & Concepts
Chimeric antigen receptorImmunotherapyAntigenReceptorImmunologyMedicineCancer researchImmune systemInternal medicineCAR-T cell therapy researchBiosimilars and Bioanalytical Methods