Combined Aurora Kinase A and CHK1 Inhibition Enhances Radiosensitivity of Triple-Negative Breast Cancer Through Induction of Apoptosis and Mitotic Catastrophe Associated With Excessive DNA Damage
Chunyan Li, Jiatao Liao, Xuanyi Wang, Fei Chen, Xiaomao Guo, Xing‐Xing Chen
Topics & Concepts
Mitotic catastropheRadiosensitivityCancer researchCHEK1KinaseMAPK/ERK pathwayTriple-negative breast cancerApoptosisDNA damagePI3K/AKT/mTOR pathwayMedicineCell cycleBiologyCell cycle checkpointCancerCell biologyBreast cancerRadiation therapyInternal medicineGeneticsDNAMicrotubule and mitosis dynamicsCancer, Hypoxia, and MetabolismDNA Repair Mechanisms