Cobalt(III)-Catalyzed Directed C-7 Selective C–H Alkynylation of Indolines with Bromoalkynes
Ruihan Niu, Jing Zhang, Ruyuan Zhao, Quanjian Luo, Jin‐Heng Li, Bo Sun
Abstract
A cobalt(III)-catalyzed directed C-7 alkynylation of indolines with easily accessible bromoalkynes has been developed. The reaction has a broad substrate scope with excellent yields and represents a powerful route to the synthesis of 7-alkynyl-substituted indolines. In addition, the reaction can be extended to the coupling of N -aryl 7-azaindoles, highlighting the synthetic practicability of the strategy.
Topics & Concepts
ChemistryAlkynylationCatalysisCobaltCombinatorial chemistrySubstrate (aquarium)ArylScope (computer science)Reaction conditionsCoupling reactionOrganic chemistryOceanographyProgramming languageComputer scienceGeologyAlkylCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques