Aliphatic <sup>18</sup>F‐Radiofluorination: Recent Advances in the Labeling of Base‐Sensitive Substrates**
Klas Bratteby, Vladimir Shalgunov, Matthias M. Herth
Abstract
Abstract Aliphatic fluorine‐18 radiolabeling is the most commonly used method to synthesize tracers for PET‐imaging. With an increasing demand for 18 F‐radiotracers for clinical applications, new labeling strategies aiming to increase radiochemical yields of established tracers or, more importantly, to enable 18 F‐labeling of new scaffolds have been developed. In recent years, increased attention has been focused on the direct aliphatic 18 F‐fluorination of base‐sensitive substrates in this respect. This minireview gives a concise overview of the recent advances within this field and aims to highlight the advantages and limitations of these methods.
Topics & Concepts
Base (topology)ChemistryCombinatorial chemistryComputer scienceMathematicsMathematical analysisFluorine in Organic ChemistryRadiopharmaceutical Chemistry and ApplicationsChemical Synthesis and Analysis