Oncogenic SNORD12B activates the AKT-mTOR-4EBP1 signaling in esophageal squamous cell carcinoma via nucleus partitioning of PP-1α
Baoqing Tian, Jiandong Liu, Nasha Zhang, Yemei Song, Yeyang Xu, Mengyu Xie, Bowen Wang, Hui Hua, Yue Shen, Yankang Li, Ming Yang
Topics & Concepts
BiologyPI3K/AKT/mTOR pathwayProtein kinase BCancer researchSmall nucleolar RNACarcinogenesisAKT2OncogeneProtein phosphatase 2CancerLong non-coding RNASignal transductionCell biologyPhosphorylationCell cycleDownregulation and upregulationAKT1PhosphataseGeneticsGeneRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing