Rescue by elexacaftor-tezacaftor-ivacaftor of the G1244E cystic fibrosis mutation's stability and gating defects are dependent on cell background
Valeria Tomati, Stefano Costa, Valeria Capurro, Emanuela Pesce, Cristina Pastorino, Mariateresa Lena, Elvira Sondo, Marco Di Duca, Federico Cresta, Simona Cristadoro, Federico Zara, Luis J. V. Galietta, Renata Bocciardi, Carlo Castellani, Maria Cristina Lucanto, Nicoletta Pedemonte
Topics & Concepts
PotentiatorIvacaftorCystic fibrosisCystic fibrosis transmembrane conductance regulatorGatingMutantMutationChloride channelCell biologyHeterologousMedicineHeterologous expressionMutagenesisTransmembrane proteinChemistryBiologyPharmacologyBiochemistryInternal medicineReceptorGeneRecombinant DNAPhysiologyCystic Fibrosis Research AdvancesNeonatal Respiratory Health ResearchBacterial biofilms and quorum sensing