Dihydrostilbene glycosides from <i>Camellia sasanqua</i> and their <i>α</i> -glucosidase and <i>α</i> -amylase inhibitory activities
Nguyễn Thị Cúc, Nguyen The Cuong, Luu Thế Anh, Dương Thị Hải Yến, Bùi Hữu Tài, Duong Thu Trang, Phạm Hải Yến, Phan Văn Kiệm, Nguyễn Hoài Nam, Châu Văn Minh, Nguyễn Xuân Nhiệm
Abstract
Using chromatographic methods, three new dihydrostilbene glycosides, sasastilbosides A-C (1-3) and four known compounds, catechin (4), rutin (5), nicotiflorin (6), and rehmaionoside A (7) have been isolated from Camellia sasanqua Thunb. Their chemical structures were elucidated by spectroscopic methods (1 D-, 2 D-NMR) and mass spectra. Compounds 1-7 were evaluated for α-glucosidase and α-amylase inhibitory effects. Compounds 3 and 4 showed α-glucosidase inhibitory activity with IC50 values of 77.6 ± 1.6 and 72.4 ± 1.3 μM, respectively. Compound 1 showed α-amylase inhibitory activity with IC50 value of 53.7 ± 1.6 μM.