Refinement of the 8th AJCC Staging System for Medullary Thyroid Cancer: Integrating Tumor Size and Lymph Node Characteristics with SEER and Multicenter Validation
Noor Aisyah Abdullah, Muhammad Irfan Zulkifli, Ahmad Husaini Mohamed
Abstract
The 2018 release of the 8th edition of the AJCC staging system for medullary thyroid cancer (MTC) aimed to standardize prognosis assessment. However, its effectiveness in predicting patient outcomes is still debated. Patient records were extracted from both the SEER database and multicenter cohorts. The study’s main endpoint was overall survival (OS). Prognostic performance of different staging models was evaluated using the concordance index (C-index). A total of 1450 MTC cases were included fr
Topics & Concepts
MedicineConcordanceMedullary cavityStaging systemLymph nodeMedullary thyroid cancerMulticenter studyThyroidRadiologyOncologyThyroid cancerOverall survivalAJCC staging systemCancerInternal medicineClinical endpointStage (stratigraphy)TNM staging systemSurvival analysisCancer stagingLymphPatient dataThyroid carcinomaNeoplasm stagingSurvival rateThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid SurgeryRenal cell carcinoma treatment