Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer
Yiqing Tan, Ran Sun, Lei Liu, Dejuan Yang, Xiang Qin, Li Li, Jun Tang, Zhu Qiu, Weiyan Peng, Yuanyuan Wang, Lin Ye, Guosheng Ren, Tingxiu Xiang
Abstract
Collectively, this study novelly manifests the role of DRD2 in suppressing BrCa tumorigenesis, predicting prognosis and treatment response. And this study further reveals the critical role of DRD2 in educating M1 macrophages, restricting NF-κB signaling pathway and triggering different processes of programmed cell death in BrCa. Taking together, those findings represent a predictive and therapeutic target for BrCa.
Topics & Concepts
Cancer researchPyroptosisCarcinogenesisBreast cancerDNA methylationMedicineBiologyCancerApoptosisOncologyInternal medicineGene expressionProgrammed cell deathGeneBiochemistryInflammasome and immune disordersImmune cells in cancerFerroptosis and cancer prognosis