Molecular Pathogenesis of Gastrointestinal Stromal Tumor: A Paradigm for Personalized Medicine
Josephine K. Dermawan, Brian P. Rubin
Abstract
Over the past three to four decades, the molecular pathogenesis of gastrointestinal stromal tumors (GISTs) has been elucidated in great detail. In this review, we discuss the biological genesis of GISTs, identification of the various primary activating driver mutations (focusing on KIT and PDGFRA), oncogene addiction and targeted therapies with imatinib and other tyrosine kinase inhibitors, and the subsequent characterization of the various mechanisms of drug resistance. We illustrate how GIST has become a quintessential paradigm for personalized medicine.
Topics & Concepts
GiSTPDGFRAImatinibStromal tumorPathogenesisPrecision medicineStromal cellPersonalized medicineCancer researchTyrosine-kinase inhibitorTyrosine kinaseMedicineBioinformaticsBiologyCancerImmunologyPathologyInternal medicineReceptorMyeloid leukemiaGastrointestinal Tumor Research and TreatmentSarcoma Diagnosis and TreatmentNeurofibromatosis and Schwannoma Cases