Synthesis of Benzofuran Derivates via a Gold-Catalyzed Claisen Rearrangement Cascade
Yankun Li, Chen‐Ho Tung, Zhenghu Xu
Abstract
A novel method toward a facile synthesis of diverse benzofuran derivates from easily obtained quinols and alkynyl esters has been reported. A gold-catalyzed intermolecular alkoxylation/Claisen rearrangement/condensation cascade was involved. The introduction of difluorodiphenylsilane as a water-trapping reagent in the reaction leads to a higher yield.
Topics & Concepts
ChemistryBenzofuranReagentClaisen rearrangementCatalysisCascadeYield (engineering)Combinatorial chemistryIntermolecular forceCondensationOrganic chemistryMoleculeMaterials scienceThermodynamicsMetallurgyPhysicsChromatographyCatalytic Alkyne ReactionsCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods