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Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

Genzui Setsu, Megumi Goto, Kentaro Ito, Tomoe Taira, Masaya Miyamoto, Tomohiro Watanabe, Toru Taniguchi, Yuma Umezaki, Yusuke Nakazawa, Shuhei Uesugi, Kazuki Mori, Takao Horiuchi, Wataru Obuchi, Masako Minami, Takashi Shimada, Chisa Wada, Takanori Yoshida, Saito Higuchi

2023European Journal of Pharmacology19 citationsDOI

Topics & Concepts

ImmunotherapyCancer immunotherapyImmune systemBiologyT cellCancer researchCancerTumor microenvironmentCytokineImmune checkpointCancer cellPharmacologyImmunologyGeneticsCancer Cells and MetastasisMelanoma and MAPK PathwaysColorectal Cancer Treatments and Studies
Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models | Litcius