Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia
Angélica Rico, Sheila C. Dollard, Diana Valencia, Sheryll Corchuelo, Van T. Tong, Katherine Laiton‐Donato, Minal M. Amin, Mónica Benavides, Phili Wong, Suzanne Newton, Marcela Daza, Jordan Cates, Maritza González, Laura D. Zambrano, Marcela Mercado, Elizabeth C. Ailes, Helena Martínez Rodríguez, Suzanne M. Gilboa, Jacqueline Acosta, Jessica N. Ricaldi, Dioselina Peláez, Margaret A. Honein, Martha Ospina, Tatiana M. Lanzieri
Abstract
We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8-12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%-98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%-18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%-59.1%) had postnatal infection.