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GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity

Michelle J. Cox, Claudia Manriquez Roman, Erin E. Tapper, Elizabeth L. Siegler, Dale Chappell, Cameron Durrant, Omar Abdihamid, Sutapa Sinha, Raphael Mwangi, Nancy E. Scott, Mehrdad Hefazi, Kendall J. Schick, Paulina Horvei, Michael W. Ruff, İsmail Can, Mohamad M. Adada, Evandro D. Bezerra, Lionel Aurelien Kankeu Fonkoua, Sameer A. Parikh, Neil E. Kay, Reona Sakemura, Saad S. Kenderian

2022Leukemia38 citationsDOIOpen Access PDF

Topics & Concepts

CartMyeloidDownregulation and upregulationCD19Chimeric antigen receptorCancer researchHaematopoiesisReceptorCellT cellBiologyGranulocyte macrophage colony-stimulating factorImmunologyCell biologyCytokineAntigenStem cellImmune systemMechanical engineeringEngineeringGeneticsBiochemistryGeneCAR-T cell therapy researchImmune Cell Function and InteractionVirus-based gene therapy research
GM-CSF disruption in CART cells modulates T cell activation and enhances CART cell anti-tumor activity | Litcius