Binuclear and tetranuclear Zn(<scp>ii</scp>) complexes with thiosemicarbazones: synthesis, X-ray crystal structures, ATP-sensing, DNA-binding, phosphatase activity and theoretical calculations
Piyali Adak, Bipinbihari Ghosh, Antonio Bauzá, Antonio Frontera, Steven R. Herron, Shyamal Kumar Chattopadhyay
Abstract
A binuclear and a tetranuclear zinc(<sc>ii</sc>) of pyruvaldehyde thiosemicarbazone show selective sensing of ATP at pH 7.4 (0.01 M HEPES) in CH<sub>3</sub>CN–H<sub>2</sub>O (9 : 1) medium. The DNA binding and phosphatase activities of the complexes are also reported.
Topics & Concepts
PhosphataseChemistryDNAX-rayCrystallographyStereochemistryEnzymeDNA synthesisBiochemistryPhysicsQuantum mechanicsMetal complexes synthesis and propertiesMagnetism in coordination complexesDNA and Nucleic Acid Chemistry