Comparison of Three β-Glucan Tests for the Diagnosis of Invasive Candidiasis in Intensive Care Units
Antonios Kritikos, Giorgia Caruana, Julien Poissy, A. Mamin, Daniel Bachmann, Jean‐Luc Pagani, Alix T. Coste, Frédéric Lamoth
Abstract
= 0.89, respectively). For the recommended cutoffs of positivity, sensitivity and specificity for IC diagnosis were 77%/51% (FA, 80 pg/mL), 69%/53% (STAT, ratio 1.2), and 54%/65% (WA, 7 pg/mL), respectively. Optimal performance was obtained at 50 pg/mL (FA), ratio 1.3 (STAT), and 3.3 pg/mL (WA) with sensitivity/specificity of 85%/51%, 69%/57%, and 77%/58%, respectively. Overall, the three BDG tests showed comparable but limited performance in this setting with positive and negative predictive values for an estimated IC prevalence of 20% that were in the range of 30 to 35% and 85 to 95%, respectively.
Topics & Concepts
MedicineIntensive care unitInternal medicineGastroenterologyInvasive candidiasisAntifungalFluconazoleDermatologyAntifungal resistance and susceptibilityMedicinal Plants and NeuroprotectionProbiotics and Fermented Foods