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Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study

Hanan Gaber Abdulwahab, Marwa F. Harras, Nagwan G. El Menofy, Amany M. Hegab, Basma M. Essa, Adli A. Selim, Tamer M. Sakr, Heba S. A. Elzahabi

2020Bioorganic & Medicinal Chemistry37 citationsDOI

Topics & Concepts

UreaseChemistryThioureaBiodistributionEnzymeAntibacterial activityBacteriaMorpholineIC50BiochemistryAntibacterial agentCombinatorial chemistryStereochemistryOrganic chemistryAntibioticsIn vitroBiologyGeneticsMicrobial Applications in Construction MaterialsSynthesis and Characterization of Heterocyclic CompoundsEnzyme function and inhibition
Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study | Litcius