Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study
Hanan Gaber Abdulwahab, Marwa F. Harras, Nagwan G. El Menofy, Amany M. Hegab, Basma M. Essa, Adli A. Selim, Tamer M. Sakr, Heba S. A. Elzahabi
Topics & Concepts
UreaseChemistryThioureaBiodistributionEnzymeAntibacterial activityBacteriaMorpholineIC50BiochemistryAntibacterial agentCombinatorial chemistryStereochemistryOrganic chemistryAntibioticsIn vitroBiologyGeneticsMicrobial Applications in Construction MaterialsSynthesis and Characterization of Heterocyclic CompoundsEnzyme function and inhibition