Knockdown of CALM2 increases the sensitivity to afatinib in HER2-amplified gastric cancer cells by regulating the Akt/FoxO3a/Puma axis
Jianli Sun, Qunfen Cao, Saizheng Lin, Yonghua Chen, Xiao Liu, Qiongyi Hong
Topics & Concepts
Downregulation and upregulationAfatinibGene knockdownProtein kinase BPumaPI3K/AKT/mTOR pathwayCancer researchChemistryCell biologyApoptosisBiologyCancerSignal transductionBiochemistryGeneticsEpidermal growth factor receptorErlotinibGeneFOXO transcription factor regulationMicroRNA in disease regulationMechanisms of cancer metastasis