Investigating the anticancer potential of 4-phenylthiazole derived Ru(<scp>ii</scp>) and Os(<scp>ii</scp>) metalacycles
Paul Getreuer, Laura Marretta, Emine Toyoglu, Orsolya Dömötör, Michaela Hejl, Alexander Roller, Klaudia Cseh, Anton A. Legin, Michael A. Jakupec, Giampaolo Barone, Alessio Terenzi, Bernhard K. Keppler, Wolfgang Kandioller
Abstract
4-Phenylthiazole-based metalacycles were synthesized, characterized and examined for their anticancer potential. Preliminary mode of action studies to reveal the cellular target of these complexes were performed.
Topics & Concepts
ChemistryAction (physics)StereochemistryMode of actionMedicinal chemistryPhysicsBiochemistryQuantum mechanicsMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsClick Chemistry and Applications