Uncoupling protein-1 expression does not protect mice from diet-induced obesity
Hui Wang, Monja Willershäuser, Yongguo Li, Tobias Fromme, Katharina Schnabl, Andrea Bast‐Habersbrunner, Samira Ramisch, Sabine Mocek, Martin Klingenspor
Abstract
To study the functional role of UCP1-dependent brown adipose tissue thermogenesis for energy balance, new animal models are needed. By metabolic phenotyping of a novel mouse model with low UCP1 levels in brown fat, we demonstrate that the susceptibility to diet-induced obesity is not increased despite impaired cold-induced thermogenic capacity. Brown fat requires pharmacological activation to promote negative energy balance in diet-induced obese mice.
Topics & Concepts
ThermogeninThermogenesisBrown adipose tissueEndocrinologyInternal medicineReporter geneAdipose tissueBiologyGene expressionChemistryGeneMedicineBiochemistryAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity