The new N2, N4-diphenylpyridine-2,4-diamine deuterated derivatives as EGFR inhibitors to overcome C797S-mediated resistance
Jiadai Liu, Wenyan Nie, Haoran Nie, Han Yao, Yuanyuan Ren, Longcai Cao, Jiaqi Qiu, Mengxuan Wang, Xingshu Li, Baijiao An, Xian Jia
Topics & Concepts
ChemistryT790MKinasePharmacologyIC50Cell cycle checkpointApoptosisIn vitroBiochemistryEpidermal growth factor receptorCell cycleReceptorBiologyGefitinibLung Cancer Treatments and MutationsRadiopharmaceutical Chemistry and ApplicationsCancer therapeutics and mechanisms