Disulfidptosis: a new target for metabolic cancer therapy
Peijie Zheng, Chuntao Zhou, Yuemin Ding, Shiwei Duan
Abstract
Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic therapy. A recent study has identified a new metabolic-related RCD known as disulfidptosis. Preclinical findings suggest that metabolic therapy using glucose transporter (GLUT) inhibitors can trigger disulfidptosis and inhibit cancer growth. In this review, we summarize the specific mechanisms underlying disulfidptosis and outline potential future research directions. We also discuss the challenges that may arise in the clinical translation of disulfidptosis research.
Topics & Concepts
CancerCancer therapyMedicineCancer cellBioinformaticsTranslation (biology)Cancer researchBiologyInternal medicineBiochemistryGeneMessenger RNACancer, Hypoxia, and MetabolismEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and Therapy