Established and Emerging Treatments of Skin GvHD
Cornelia S. Link, Katja Sockel, Catharina Schuetz
Abstract
Graft-versus-host disease (GvHD) of the skin is a severe allo-immune reaction and complication following allogeneic stem cell transplantation. Over the past years, intensive pre-clinical research has led to an improved understanding of the pathophysiology of acute and to a lesser extend chronic GvHD. This has translated into the approval of several new agents for the treatment of both forms of GvHD. This review summarizes the most recent advances in underlying pathomechanisms, clinical trials and newly approved agents for GvHD, with a special focus on skin involvement.
Topics & Concepts
MedicineGraft-versus-host diseaseClinical trialDiseaseImmunologyIntensive care medicineTransplantationImmune systemHematopoietic stem cell transplantationComplicationPathologyInternal medicineHematopoietic Stem Cell TransplantationImmunotherapy and Immune ResponsesT-cell and B-cell Immunology