Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion
Sylvain Tollis, Andrea Rizzotto, Nhan T. Pham, Sonja Koivukoski, Aishwarya Sivakumar, Steven Shave, Jan Wildenhain, Nikolaj Zuleger, Jeremy Keys, Jayne Culley, Yijing Zheng, Jan Lammerding, Neil O. Carragher, Valerie G. Brunton, Leena Latonen, Manfred Auer, Mike Tyers, Eric C. Schirmer
Abstract
: Our study provides (a) proof of concept that nuclear size might be a valuable target to reduce cell migration/invasion in cancer treatment and (b) the most thorough collection of tool compounds to date reversing nuclear size changes specific to individual cancer-type cell lines. Although these compounds still need to be tested in primary cancer cells, the cell line-specific nuclear size and migration/invasion responses to particular drug classes suggest that cancer type-specific nuclear size rectifiers may help reduce metastatic spread.