Dual photothermal nanocomposites for drug-resistant infectious wound management
Changgui Li, Jiaru Xian, Jixuan Hong, Xiaxin Cao, Changze Zhang, Qiaoyuan Deng, Ziyu Qin, Maohua Chen, Xiaofei Zheng, Mengting Li, Jingwei Hou, Yinghong Zhou, Xueqiong Yin
Abstract
as demonstrated by a cell survival ratio of >85%. The effectiveness of the composite membranes on wound healing was further investigated in a murine model of MRSA-infected wounds, focusing on the effect of photothermal temperature. According to the detailed therapeutic mechanism study undertaken, the composite membranes cause bacterial killing initially and promote the transition from the inflammatory phase to proliferation by suppressing pro-inflammatory cytokine production, promoting collagen deposition, and stimulating angiogenesis. Considering their remarkable effectiveness and facile fabrication process, it is expected that these novel materials could serve as competitive multifunctional dressings in the management of infectious wounds and accelerate the regeneration of damaged tissues related to abnormal immune responses.